Poon Goor Soe was founded in 1890 by late- Qing dynasty , by the Guangdong Poon Bai Shi Guangzhou and his brother, who began the first High Street pharmacy , shop number " Changchuntong Poon Goor Soe" (meaning : eternal live in Spring time, long life).
Subsequently Poon Yu Sheng, son of Poon Bai Shi took over the business, and developed a new drugs "Pei Pa Lo ". It was during the World War II , Poon Yu Sheng and his sons moved to Hong Kong respectively. The pharmaceutical company began the Hong Kong operation in the early 1950s, the name Poon Goor Soe substituted Changchuntong Poon Goor Soe.